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  • A2

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    강연 주제 경구 전달 시 펩타이드 흡수 촉진 - 사례 연구 접근법
    강의 일정 2025.08.26(11:40-12:10) | A홀 세미나룸
    소속 중앙대학교
    연사명 이상길 교수
    연사 및 강연 소개

    [주제 세부 소개]

    Lipid-based excipients have emerged as key enablers in the advancement of modern drug delivery systems, offering unique physicochemical properties that make them especially suitable for complex therapeutic applications. Among their many uses, their role in the oral delivery of biopharmaceuticals has seen remarkable growth in recent years. This is particularly significant given the challenges associated with delivering biopharmaceuticals, such as insulin, which are typically large, hydrophilic, and structurally unstable molecules. These properties make them highly susceptible to enzymatic degradation and poor absorption in the gastrointestinal tract, thereby necessitating the development of robust stabilization and delivery strategies.

    Lipid excipients not only provide a protective matrix and controlled release profile but also contribute to enhancing the permeability and bioavailability of encapsulated drugs. In addition to being used as primary components in the formulation of delivery systems, lipids are now being more actively explored as functional excipients that can synergize with other technologies to improve overall delivery performance.

    This presentation focuses on insulin as a model biopharmaceutical and introduces recent advances in oral delivery strategies using lipid-based approaches. In particular, it will highlight the effectiveness of specific lipid excipients in enhancing the performance of Hydrophobic Ion Pairing (HIP) technology. By forming complexes that increase the lipophilicity and stability of insulin, HIP combined with lipids represents a promising strategy to overcome traditional barriers to oral protein delivery. Case studies from recent experimental research will be presented to demonstrate the practical benefits and future potential of lipid-assisted HIP systems in biopharmaceuticals formulation. 

     

    [연사 소개]

    Professor Lee received a bachelor's degree from College of Pharmacy, Chung-Ang University in 1997, followed by a master's and Ph.D. in Pharmacy from the same institution. After completing his academic training, he gained four years of industry experience at Daewoong pharmaceutical company, where he was involved in hands-on research and development. He then held academic positions at department of pharmaceutical engineering, Inje university and College of pharmacy, Keimyung University before joining Chung-Ang University, where he currently serves as a full professor. His primary research interests focus on the brain drug delivery, cancertherapy to overcome resistant ovarian cancer, and he has conducted extensive studies on oral peptide drug delivery systems using lipid-based materials.

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