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    강연 주제 펩타이드 전달 강화: 지질 기반 부형제의 다기능 역할
    강의 일정 2025.08.26(11:00-11:30) | A홀 세미나룸
    소속 가테포세
    연사명 Dr. Alexandre Gil, Group Director - Pharmaceutical
    연사 및 강연 소개

    [주제 세부 소개]

    Besides low aqueous solubility, poor absorption is a limitation to oral efficiency for a growing number of small and large molecules, including peptides, which are also prone to degradation in the GI tract. Multifunctional lipid excipients, particularly medium-chain fatty acid esters, are emerging as promising tools to overcome these barriers.

    This presentation will briefly revisit the physiological role of tight junctions and explore how targeted modulation can enhance paracellular transport. Drawing on recent ex vivo and in vivo studies, we will showcase the efficacy and safety of these lipid-based excipients in improving the permeation of both small molecules and peptides.

    Despite their permeation-enhancing properties being only recently elucidated, these excipients have a well-established track record in pharmaceutical development. They are present in several marketed formulations, compliant with major pharmacopeias, and manufactured by Gattefossé under responsible and sustainable practices. Their versatility allows for easy integration into both liquid and solid oral dosage forms—making them a practical and innovative solution for peptide delivery. 

     

    [연사 소개]

    PhD in Pharmaceutical Sciences, with 25 years of experience in pharmaceutical development, covering generic drugs, OTC products, veterinary medicine, pharmaceutical contract manufacturing, and prescription specialties. Career marked by responsibilities across the entire value chain, from preclinical stages to product launch, within companies such as Pierre Fabre, Ethypharm, Virbac, Sanofi, and STA Pharmaceuticals.

    Since 2022, leading the Pharmaceutical Business Unit at Gattefossé, with responsibility for global innovation and commercial development of lipid-based excipients.